2bdg: Difference between revisions

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{{Seed}}
[[Image:2bdg.png|left|200px]]


<!--
==Human Kallikrein 4 complex with nickel and p-aminobenzamidine==
The line below this paragraph, containing "STRUCTURE_2bdg", creates the "Structure Box" on the page.
<StructureSection load='2bdg' size='340' side='right'caption='[[2bdg]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2bdg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BDG FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PBZ:P-AMINO+BENZAMIDINE'>PBZ</scene></td></tr>
{{STRUCTURE_2bdg| PDB=2bdg |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdg OCA], [https://pdbe.org/2bdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bdg RCSB], [https://www.ebi.ac.uk/pdbsum/2bdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdg ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[https://omim.org/entry/204700 204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>
== Function ==
[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Involved in enamel formation.<ref>PMID:15235027</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/2bdg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bdg ConSurf].
<div style="clear:both"></div>


===Human Kallikrein 4 complex with nickel and p-aminobenzamidine===
==See Also==
 
*[[Kallikrein 3D structures|Kallikrein 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_16950394}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 16950394 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_16950394}}
 
==About this Structure==
2BDG is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDG OCA].
 
==Reference==
Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site., Debela M, Magdolen V, Grimminger V, Sommerhoff C, Messerschmidt A, Huber R, Friedrich R, Bode W, Goettig P, J Mol Biol. 2006 Oct 6;362(5):1094-107. Epub 2006 Aug 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16950394 16950394]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
[[Category: Large Structures]]
[[Category: 70-80 loop]]
[[Category: Bode W]]
[[Category: Hydrolase]]
[[Category: Debela M]]
[[Category: S1 subsite]]
[[Category: Goettig P]]
[[Category: Serine proteinase]]
[[Category: Spine]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec  3 20:06:47 2008''

Latest revision as of 06:24, 3 April 2024

Human Kallikrein 4 complex with nickel and p-aminobenzamidine

2bdg, resolution 1.95Å

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