3czv: Difference between revisions

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{{Seed}}
[[Image:3czv.png|left|200px]]


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==Crystal structure of the human carbonic anhydrase XIII in complex with acetazolamide==
The line below this paragraph, containing "STRUCTURE_3czv", creates the "Structure Box" on the page.
<StructureSection load='3czv' size='340' side='right'caption='[[3czv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3czv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CZV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3czv|  PDB=3czv |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3czv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3czv OCA], [https://pdbe.org/3czv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3czv RCSB], [https://www.ebi.ac.uk/pdbsum/3czv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3czv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAH13_HUMAN CAH13_HUMAN] Reversible hydration of carbon dioxide.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/3czv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3czv ConSurf].
<div style="clear:both"></div>


===Crystal structure of the human carbonic anhydrase XIII in complex with acetazolamide===
==See Also==
 
*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_18618712}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18618712 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_18618712}}
 
==About this Structure==
3CZV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CZV OCA].
 
==Reference==
Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide., Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G, Proteins. 2008 Jul 10;74(1):164-175. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18618712 18618712]
 
Refined structure of human carbonic anhydrase II at 2.0 A resolution., Eriksson AE, Jones TA, Liljas A, Proteins. 1988;4(4):274-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3151019 3151019]
[[Category: Carbonate dehydratase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
[[Category: Large Structures]]
[[Category: Carbonic anhydrase]]
[[Category: De Simone G]]
[[Category: Lyase]]
[[Category: Di Fiore A]]
[[Category: Metal-binding]]
[[Category: Protein-inhibitor complex]]
[[Category: Zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec  3 20:17:09 2008''

Latest revision as of 09:39, 21 February 2024

Crystal structure of the human carbonic anhydrase XIII in complex with acetazolamide

3czv, resolution 2.00Å

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