2w3v: Difference between revisions

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New page: '''Unreleased structure''' The entry 2w3v is ON HOLD until Paper Publication Authors: Leung, A.K.W., Reynolds, R.C., Borhani, D.W. Description: MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCT...
 
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'''Unreleased structure'''


The entry 2w3v is ON HOLD  until Paper Publication
==MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM==
<StructureSection load='2w3v' size='340' side='right'caption='[[2w3v]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2w3v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3V FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3v OCA], [https://pdbe.org/2w3v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3v RCSB], [https://www.ebi.ac.uk/pdbsum/2w3v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O30463_MYCAV O30463_MYCAV] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3v_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w3v ConSurf].
<div style="clear:both"></div>


Authors: Leung, A.K.W., Reynolds, R.C., Borhani, D.W.
==See Also==
 
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
Description: MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM
__TOC__
 
</StructureSection>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec  3 22:48:42 2008''
[[Category: Large Structures]]
[[Category: Mycobacterium avium]]
[[Category: Borhani DW]]
[[Category: Leung AKW]]
[[Category: Reynolds RC]]
Retrieved from "https://proteopedia.org/2w3v"