3fbk: Difference between revisions
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New page: '''Unreleased structure''' The entry 3fbk is ON HOLD Authors: Forouhar, F., Lew, S., Seetharaman, J., Mao, L., Xiao, R., Ciccosanti, C., Foote, E.L., Shastry, R., Everett, J.K., Nair, R... |
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==Crystal structure of the C2 domain of the human regulator of G-protein signaling 3 isoform 6 (RGP3), Northeast Structural Genomics Consortium Target HR5550A== | |||
<StructureSection load='3fbk' size='340' side='right'caption='[[3fbk]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3fbk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FBK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fbk OCA], [https://pdbe.org/3fbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fbk RCSB], [https://www.ebi.ac.uk/pdbsum/3fbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fbk ProSAT], [https://www.topsan.org/Proteins/NESGC/3fbk TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RGS3_HUMAN RGS3_HUMAN] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:8602223</ref> <ref>PMID:9858594</ref> <ref>PMID:10749886</ref> <ref>PMID:11294858</ref> | |||
==See Also== | |||
*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Acton TB]] | |||
[[Category: Ciccosanti C]] | |||
[[Category: Everett JK]] | |||
[[Category: Foote EL]] | |||
[[Category: Forouhar F]] | |||
[[Category: Hunt JF]] | |||
[[Category: Lew S]] | |||
[[Category: Mao L]] | |||
[[Category: Montelione GT]] | |||
[[Category: Nair R]] | |||
[[Category: Rost B]] | |||
[[Category: Seetharaman J]] | |||
[[Category: Shastry R]] | |||
[[Category: Tong L]] | |||
[[Category: Xiao R]] | |||
Latest revision as of 09:33, 6 December 2023
Crystal structure of the C2 domain of the human regulator of G-protein signaling 3 isoform 6 (RGP3), Northeast Structural Genomics Consortium Target HR5550A
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