3bfi: Difference between revisions

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{{Seed}}
[[Image:3bfi.jpg|left|200px]]


<!--
==E. Coli Thymidylate Synthase Y209M mutant complexed with 5-nitro-dUMP==
The line below this paragraph, containing "STRUCTURE_3bfi", creates the "Structure Box" on the page.
<StructureSection load='3bfi' size='340' side='right'caption='[[3bfi]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3bfi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BFI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXM:N-CARBOXYMETHIONINE'>CXM</scene>, <scene name='pdbligand=NDU:2-DEOXY-5-NITROURIDINE+5-MONOPHOSPHATE'>NDU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3bfi| PDB=3bfi |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bfi OCA], [https://pdbe.org/3bfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bfi RCSB], [https://www.ebi.ac.uk/pdbsum/3bfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bfi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/3bfi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bfi ConSurf].
<div style="clear:both"></div>


===E. Coli Thymidylate Synthase Y209M mutant complexed with 5-nitro-dUMP===
==See Also==
 
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3BFI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFI OCA].
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Thymidylate synthase]]
[[Category: Large Structures]]
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
[[Category: Montfort WR]]
[[Category: Cytoplasm]]
[[Category: Roberts SA]]
[[Category: Methyltransferase]]
[[Category: Nucleotide biosynthesis]]
[[Category: Repressor]]
[[Category: Rna-binding]]
[[Category: Translation regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Dec  5 09:26:41 2008''
Retrieved from "https://proteopedia.org/3bfi"