1v38: Difference between revisions
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New page: left|200px<br /><applet load="1v38" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v38" /> '''Solution structure of the Sterile Alpha Moti... |
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== | ==Solution structure of the Sterile Alpha Motif (SAM) domain of mouse SAMSN1== | ||
<StructureSection load='1v38' size='340' side='right'caption='[[1v38]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1v38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V38 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v38 OCA], [https://pdbe.org/1v38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v38 RCSB], [https://www.ebi.ac.uk/pdbsum/1v38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v38 ProSAT], [https://www.topsan.org/Proteins/RSGI/1v38 TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SAMN1_MOUSE SAMN1_MOUSE] Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.<ref>PMID:15381729</ref> <ref>PMID:19923443</ref> <ref>PMID:20478393</ref> <ref>PMID:21296879</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v3/1v38_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v38 ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Goroncy A]] | |||
[[Category: Goroncy | [[Category: Inoue M]] | ||
[[Category: Inoue | [[Category: Kigawa T]] | ||
[[Category: Kigawa | [[Category: Kobayashi N]] | ||
[[Category: Kobayashi | [[Category: Koshiba S]] | ||
[[Category: Koshiba | [[Category: Tochio N]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Tochio | |||
[[Category: Yokoyama | |||
Latest revision as of 18:17, 29 May 2024
Solution structure of the Sterile Alpha Motif (SAM) domain of mouse SAMSN1
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