3eui: Difference between revisions

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~~{{Seed}}~~

~~[[Image:3eui.jpg|left|200px]]~~

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==A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6042 in a large unit cell==

~~The line below this paragraph~~, ~~containing~~ "~~STRUCTURE_3eui~~"~~, creates the~~ "~~Structure Box~~" ~~on the page~~.

~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)

== Structural highlights ==

~~or the SCENE parameter~~ (~~which sets the initial~~ scene ~~displayed when the page is loaded~~),

<table><tr><td colspan='2'>[[3eui]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EUI FirstGlance]. <br>

~~or leave the SCENE parameter empty for the default display~~.

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr>

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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NC5:3-[(2R)-2-ETHYLPIPERIDIN-1-YL]-N-[6-({3-[(2S)-2-ETHYLPIPERIDIN-1-YL]PROPANOYL}AMINO)ACRIDIN-3-YL]PROPANAMIDE'>NC5</scene>, <scene name='pdbligand=NCI:3,6-BIS{3-[(2R)-(2-ETHYLPIPERIDINO)]PROPIONAMIDO}ACRIDINE'>NCI</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>

~~{{STRUCTURE_3eui| PDB~~=~~3eui | SCENE~~= }}

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eui OCA], [https://pdbe.org/3eui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eui RCSB], [https://www.ebi.ac.uk/pdbsum/3eui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eui ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.

~~===A bimolecular anti~~-~~parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3~~,~~6-disubstituted acridine BSU-6042 in a large unit cell===~~

Selectivity in Ligand Recognition of G-Quadruplex Loops (dagger).,Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S Biochemistry. 2009 Feb 4. PMID:19173611<ref>PMID:19173611</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~==About this Structure==~~

</div>

~~3EUI is~~ a ~~4 chains structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca~~-~~bin~~/~~ocashort?id~~=~~3EUI OCA].~~

~~[[Category: Pdbx_ordinal=,~~ <~~PDBx:audit_author.]]~~

== References ==

~~[[Category: Anti-parallel]]~~

~~[[Category: Bimolecular]]~~

__TOC__

[[Category: ~~Bsu-6042~~]]

</StructureSection>

[[Category: ~~Bsu6042~~]]

[[Category: Large Structures]]

[[Category: ~~Dna~~]]

[[Category: Campbell NH]]

[[Category: G~~-quadruplex~~]]

[[Category: Neidle S]]

~~[[Category: Macromolecule]]~~

[[Category: Parkinson G]]

~~[[Category: Oxytricha nova]]~~

~~[[Category: Quadruplex]]~~

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Dec 5 09:41:47 2008''~~

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@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:3eui.jpg|left|200px]]
-<!--
+==A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6042 in a large unit cell==
-The line below this paragraph, containing "STRUCTURE_3eui", creates the "Structure Box" on the page.
+<StructureSection load='3eui' size='340' side='right'caption='[[3eui]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3eui]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EUI FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NC5:3-[(2R)-2-ETHYLPIPERIDIN-1-YL]-N-[6-({3-[(2S)-2-ETHYLPIPERIDIN-1-YL]PROPANOYL}AMINO)ACRIDIN-3-YL]PROPANAMIDE'>NC5</scene>, <scene name='pdbligand=NCI:3,6-BIS{3-[(2R)-(2-ETHYLPIPERIDINO)]PROPIONAMIDO}ACRIDINE'>NCI</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
-{{STRUCTURE_3eui|  PDB=3eui  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eui OCA], [https://pdbe.org/3eui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eui RCSB], [https://www.ebi.ac.uk/pdbsum/3eui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eui ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.
-===A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6042 in a large unit cell===
+Selectivity in Ligand Recognition of G-Quadruplex Loops (dagger).,Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S Biochemistry. 2009 Feb 4. PMID:19173611<ref>PMID:19173611</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-==About this Structure==
+</div>
-EUI is a 4 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUI OCA].
+<div class="pdbe-citations 3eui" style="background-color:#fffaf0;"></div>
-[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
+== References ==
-[[Category: Anti-parallel]]
+<references/>
-[[Category: Bimolecular]]
+__TOC__
-[[Category: Bsu-6042]]
+</StructureSection>
-[[Category: Bsu6042]]
+[[Category: Large Structures]]
-[[Category: Dna]]
+[[Category: Campbell NH]]
-[[Category: G-quadruplex]]
+[[Category: Neidle S]]
-[[Category: Macromolecule]]
+[[Category: Parkinson G]]
-[[Category: Oxytricha nova]]
-[[Category: Quadruplex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Dec  5 09:41:47 2008''