3e7c: Difference between revisions

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{{Seed}}
[[Image:3e7c.png|left|200px]]


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==Glucocorticoid Receptor LBD bound to GSK866==
The line below this paragraph, containing "STRUCTURE_3e7c", creates the "Structure Box" on the page.
<StructureSection load='3e7c' size='340' side='right'caption='[[3e7c]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3e7c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E7C FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=866:5-AMINO-N-[(2S)-2-({[(2,6-DICHLOROPHENYL)CARBONYL](ETHYL)AMINO}METHYL)-3,3,3-TRIFLUORO-2-HYDROXYPROPYL]-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE'>866</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_3e7c|  PDB=3e7c  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7c OCA], [https://pdbe.org/3e7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e7c RCSB], [https://www.ebi.ac.uk/pdbsum/3e7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7c ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>  
== Function ==
[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>


===Glucocorticoid Receptor LBD bound to GSK866===
==See Also==
 
*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_18952422}}
 
==About this Structure==
3E7C is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7C OCA].
 
==Reference==
The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist., Madauss KP, Bledsoe RK, Mclay I, Stewart EL, Uings IJ, Weingarten G, Williams SP, Bioorg Med Chem Lett. 2008 Dec 1;18(23):6097-9. Epub 2008 Oct 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18952422 18952422]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bledsoe, R K.]]
[[Category: Large Structures]]
[[Category: Madauss, K P.]]
[[Category: Bledsoe RK]]
[[Category: Mclay, I.]]
[[Category: Madauss KP]]
[[Category: Stewart, E L.]]
[[Category: Mclay I]]
[[Category: Williams, S P.]]
[[Category: Stewart EL]]
[[Category: Activator]]
[[Category: Williams SP]]
[[Category: Alternative initiation]]
[[Category: Alternative splicing]]
[[Category: Chromatin regulator]]
[[Category: Cytoplasm]]
[[Category: Disease mutation]]
[[Category: Dna-binding]]
[[Category: Glucocorticoid receptor]]
[[Category: Gr]]
[[Category: Lipid-binding]]
[[Category: Metal-binding]]
[[Category: Nuclear receptor]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Pseudohermaphroditism]]
[[Category: Receptor]]
[[Category: Steroid-binding]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Ubl conjugation]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Dec  5 09:56:34 2008''
Retrieved from "https://proteopedia.org/3e7c"