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New page: left|200px<br /><applet load="1v5r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v5r" /> '''Solution Structure of the Gas2 Domain of the...
 
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[[Image:1v5r.gif|left|200px]]<br /><applet load="1v5r" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1v5r" />
'''Solution Structure of the Gas2 Domain of the Growth Arrest Specific 2 Protein'''<br />


==About this Structure==
==Solution Structure of the Gas2 Domain of the Growth Arrest Specific 2 Protein==
1V5R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1V5R OCA].  
<StructureSection load='1v5r' size='340' side='right'caption='[[1v5r]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1v5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V5R FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5r OCA], [https://pdbe.org/1v5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v5r RCSB], [https://www.ebi.ac.uk/pdbsum/1v5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v5r ProSAT], [https://www.topsan.org/Proteins/RSGI/1v5r TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GAS2_MOUSE GAS2_MOUSE] May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May play a role in chondrocyte proliferation and differentiation, and in limb myogenesis. May be involved in the regulation of the apoptosis in the interdigital tissues of the developing hindlimb. May be involved in the membrane ruffling process.<ref>PMID:10049561</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/1v5r_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v5r ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Inoue M]]
[[Category: Inoue, M.]]
[[Category: Kigawa T]]
[[Category: Kigawa, T.]]
[[Category: Koshiba S]]
[[Category: Koshiba, S.]]
[[Category: Miyamoto K]]
[[Category: Miyamoto, K.]]
[[Category: Yokoyama S]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Yokoyama, S.]]
[[Category: ZN]]
[[Category: apoptosis]]
[[Category: cell cycle]]
[[Category: gas2 domain]]
[[Category: growth arrest]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: zinc binding domain]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 04:27:21 2007''
Retrieved from "https://proteopedia.org/1v5r"