3emn: Difference between revisions

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{{Seed}}
[[Image:3emn.jpg|left|200px]]


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==The Crystal Structure of Mouse VDAC1 at 2.3 A resolution==
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<StructureSection load='3emn' size='340' side='right'caption='[[3emn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3emn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EMN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr>
{{STRUCTURE_3emn|  PDB=3emn  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3emn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3emn OCA], [https://pdbe.org/3emn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3emn RCSB], [https://www.ebi.ac.uk/pdbsum/3emn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3emn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VDAC1_MOUSE VDAC1_MOUSE] Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.<ref>PMID:10716730</ref> <ref>PMID:15477379</ref> <ref>PMID:18988731</ref>  


===The Crystal Structure of Mouse VDAC1 at 2.3 A resolution===
==See Also==
 
*[[Ion channels 3D structures|Ion channels 3D structures]]
 
== References ==
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_18988731}}
 
==About this Structure==
3EMN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMN OCA].
 
==Reference==
The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating., Ujwal R, Cascio D, Colletier JP, Faham S, Zhang J, Toro L, Ping P, Abramson J, Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17742-7. Epub 2008 Nov 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18988731 18988731]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Abramson, J.]]
[[Category: Abramson J]]
[[Category: Cascio, D.]]
[[Category: Cascio D]]
[[Category: Colletier, J P.]]
[[Category: Colletier J-P]]
[[Category: Faham, S.]]
[[Category: Faham S]]
[[Category: Ping, P.]]
[[Category: Ping P]]
[[Category: Toro, L.]]
[[Category: Toro L]]
[[Category: Ujwal, R.]]
[[Category: Ujwal R]]
[[Category: Zhang, J.]]
[[Category: Zhang J]]
[[Category: Acetylation]]
[[Category: Alternative splicing]]
[[Category: Apoptosis]]
[[Category: Beta barrel]]
[[Category: Channel]]
[[Category: Eukaryotic membrane protein]]
[[Category: Ion transport]]
[[Category: Mitochondrion]]
[[Category: Outer membrane]]
[[Category: Phosphoprotein]]
[[Category: Porin]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Vdac1]]
 
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Retrieved from "https://proteopedia.org/3emn"