3cvh: Difference between revisions

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{{Seed}}
[[Image:3cvh.png|left|200px]]


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==How TCR-like antibody recognizes MHC-bound peptide==
The line below this paragraph, containing "STRUCTURE_3cvh", creates the "Structure Box" on the page.
<StructureSection load='3cvh' size='340' side='right'caption='[[3cvh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3cvh]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CVH FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvh OCA], [https://pdbe.org/3cvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cvh RCSB], [https://www.ebi.ac.uk/pdbsum/3cvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvh ProSAT]</span></td></tr>
{{STRUCTURE_3cvh|  PDB=3cvh  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE] Involved in the presentation of foreign antigens to the immune system.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/3cvh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cvh ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We determined the crystal structures of the T cell receptor (TCR)-like antibody 25-D1.16 Fab fragment bound to a complex of SIINFEKL peptide from ovalbumin and the H-2K(b) molecule. Remarkably, this antibody directly "reads" the structure of the major histocompatibility complex (MHC)-bound peptide, employing the canonical diagonal binding mode utilized by most TCRs. This is in marked contrast with another TCR-like antibody, Hyb3, bound to melanoma peptide MAGE-A1 in association with HLA-A1 MHC class I. Hyb3 assumes a non-canonical orientation over its cognate peptide-MHC and appears to recognize a conformational epitope in which the MHC contribution is dominant. We conclude that TCR-like antibodies can recognize MHC-bound peptide via two different mechanisms: one is similar to that exploited by the preponderance of TCRs and the other requires a non-canonical antibody orientation over the peptide-MHC complex.


===How TCR-like antibody recognizes MHC-bound peptide===
How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide.,Mareeva T, Martinez-Hackert E, Sykulev Y J Biol Chem. 2008 Oct 24;283(43):29053-9. Epub 2008 Aug 14. PMID:18703505<ref>PMID:18703505</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3cvh" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_18703505}}, adds the Publication Abstract to the page
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 18703505 is the PubMed ID number.
*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC I 3D structures|MHC I 3D structures]]
{{ABSTRACT_PUBMED_18703505}}
== References ==
 
<references/>
==About this Structure==
__TOC__
3CVH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVH OCA].
</StructureSection>
 
==Reference==
How a TCR-like antibodies recognizes MHC-bound peptide., Mareeva T, Martinez-Hackert E, Sykulev Y, J Biol Chem. 2008 Aug 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18703505 18703505]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Mareeva T]]
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
[[Category: Martinez-Hackert E]]
[[Category: Acetylation]]
[[Category: Sykulev Y]]
[[Category: Allergen]]
[[Category: Glycoprotein]]
[[Category: Immune response]]
[[Category: Immune system]]
[[Category: Immunoglobulin domain]]
[[Category: Membrane]]
[[Category: Mhc]]
[[Category: Mhc i]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Secreted]]
[[Category: Tcr]]
[[Category: Transmembrane]]
 
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Retrieved from "https://proteopedia.org/3cvh"