3fkc: Difference between revisions

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<!--
==Crystal Structure of Human Zinc finger and BTB domain containing 33==
The line below this paragraph, containing "STRUCTURE_3fkc", creates the "Structure Box" on the page.
<StructureSection load='3fkc' size='340' side='right'caption='[[3fkc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3fkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FKC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fkc OCA], [https://pdbe.org/3fkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fkc RCSB], [https://www.ebi.ac.uk/pdbsum/3fkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fkc ProSAT]</span></td></tr>
{{STRUCTURE_3fkc|  PDB=3fkc  |  SCENE=  }}
</table>
 
== Function ==
===Crystal Structure of Human Zinc finger and BTB domain containing 33===
[https://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
3FKC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKC OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/3fkc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fkc ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Bullock, A.]]
[[Category: Bountra C]]
[[Category: Burgess-Brown, N.]]
[[Category: Bullock A]]
[[Category: Delft, F Von.]]
[[Category: Burgess-Brown N]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Filippakopoulos, P.]]
[[Category: Filippakopoulos P]]
[[Category: Keates, T.]]
[[Category: Keates T]]
[[Category: Knapp, S.]]
[[Category: Knapp S]]
[[Category: Muniz, J.]]
[[Category: Muniz J]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Activator]]
[[Category: Cytoplasm]]
[[Category: Dna-binding]]
[[Category: Kaiso transcription factor]]
[[Category: Metal-binding]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Repressor]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Wnt signaling pathway]]
[[Category: Wugsc:h_dj525n14 1]]
[[Category: Zinc]]
[[Category: Zinc finger and btb domain containing 33]]
[[Category: Zinc-finger]]
[[Category: Znf-kaiso]]
[[Category: Znf348]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:39:24 2008''

Latest revision as of 06:47, 6 September 2023

Crystal Structure of Human Zinc finger and BTB domain containing 33

3fkc, resolution 1.70Å

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