3fke: Difference between revisions
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New page: '''Unreleased structure''' The entry 3fke is ON HOLD Authors: Amarasinghe, G.K., Leung, D.W., Ginder, N.D., Honzatko, R.B., Nix, J., Basler, C.F., Fulton, D.B. Description: Structure o... |
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==Structure of the Ebola VP35 Interferon Inhibitory Domain== | |||
<StructureSection load='3fke' size='340' side='right'caption='[[3fke]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3fke]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. The October 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ebola Virus Proteins'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_10 10.2210/rcsb_pdb/mom_2014_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FKE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fke OCA], [https://pdbe.org/3fke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fke RCSB], [https://www.ebi.ac.uk/pdbsum/3fke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fke ProSAT]</span></td></tr> | |||
'' | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ebola Virus Proteins]] | |||
[[Category: Ebola virus - Mayinga, Zaire, 1976]] | |||
[[Category: Large Structures]] | |||
[[Category: RCSB PDB Molecule of the Month]] | |||
[[Category: Amarasinghe GK]] | |||
[[Category: Basler CF]] | |||
[[Category: Fulton DB]] | |||
[[Category: Ginder ND]] | |||
[[Category: Honzatko RB]] | |||
[[Category: Leung DW]] | |||
[[Category: Nix J]] | |||
Latest revision as of 09:49, 21 February 2024
Structure of the Ebola VP35 Interferon Inhibitory Domain
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