3fia: Difference between revisions

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{{Seed}}
[[Image:3fia.jpg|left|200px]]


<!--
==Crystal structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646e.==
The line below this paragraph, containing "STRUCTURE_3fia", creates the "Structure Box" on the page.
<StructureSection load='3fia' size='340' side='right'caption='[[3fia]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3fia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FIA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3fia| PDB=3fia |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fia OCA], [https://pdbe.org/3fia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fia RCSB], [https://www.ebi.ac.uk/pdbsum/3fia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fia ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/3fia_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fia ConSurf].
<div style="clear:both"></div>


===Crystal structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646e.===
==See Also==
 
*[[Intersectin|Intersectin]]
 
== References ==
==About this Structure==
<references/>
3FIA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FIA OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Acton, T B.]]
[[Category: Large Structures]]
[[Category: Chen, Y.]]
[[Category: Acton TB]]
[[Category: Ciccosanti, C.]]
[[Category: Chen Y]]
[[Category: Devices, C.]]
[[Category: Ciccosanti C]]
[[Category: Foote, E L.]]
[[Category: Devices C]]
[[Category: Hunt, J F.]]
[[Category: Foote EL]]
[[Category: Mao,L.]]
[[Category: Hunt JF]]
[[Category: Montelione, G T.]]
[[Category: Mao L]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Montelione GT]]
[[Category: Seetharaman, J.]]
[[Category: Seetharaman J]]
[[Category: Tong, L.]]
[[Category: Tong L]]
[[Category: Vorobiev, S M.]]
[[Category: Vorobiev SM]]
[[Category: Xiao, R.]]
[[Category: Xiao R]]
[[Category: Zhao, L.]]
[[Category: Zhao L]]
[[Category: Alternative splicing]]
[[Category: Calcium]]
[[Category: Cell junction]]
[[Category: Cell projection]]
[[Category: Coiled coil]]
[[Category: Eh 1 domain]]
[[Category: Endocytosis]]
[[Category: Intersectin-1]]
[[Category: Membrane]]
[[Category: Nesg]]
[[Category: Northeast structural genomics consortium]]
[[Category: Phosphoprotein]]
[[Category: Protein binding]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Sh3 domain]]
[[Category: Structural genomic]]
[[Category: Synapse]]
[[Category: Synaptosome]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 10:40:07 2008''
Retrieved from "https://proteopedia.org/3fia"