1ntj: Difference between revisions

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{{Seed}}
[[Image:1ntj.png|left|200px]]


<!--
==Model of rat Crry determined by solution scattering, curve fitting and homology modelling==
The line below this paragraph, containing "STRUCTURE_1ntj", creates the "Structure Box" on the page.
<StructureSection load='1ntj' size='340' side='right'caption='[[1ntj]], [[Resolution|resolution]] 30.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ntj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTJ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering, [[Resolution|Resolution]] 30&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ntj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntj OCA], [https://pdbe.org/1ntj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ntj RCSB], [https://www.ebi.ac.uk/pdbsum/1ntj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntj ProSAT]</span></td></tr>
{{STRUCTURE_1ntj|  PDB=1ntj  |  SCENE=  }}
</table>
 
== Function ==
===Model of rat Crry determined by solution scattering, curve fitting and homology modelling===
[https://www.uniprot.org/uniprot/CR1L_RAT CR1L_RAT] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance.<ref>PMID:15474557</ref> <ref>PMID:7534798</ref> <ref>PMID:8144902</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_12767833}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 12767833 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/1ntj_consurf.spt"</scriptWhenChecked>
-->
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_12767833}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ntj ConSurf].
1NTJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTJ OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy., Aslam M, Guthridge JM, Hack BK, Quigg RJ, Holers VM, Perkins SJ, J Mol Biol. 2003 Jun 6;329(3):525-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12767833 12767833]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Aslam M]]
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
[[Category: Guthridge JM]]
[[Category: Ccp]]
[[Category: Hack BK]]
[[Category: Complement]]
[[Category: Holers VM]]
[[Category: Glycoprotein]]
[[Category: Perkins SJ]]
[[Category: Immune system]]
[[Category: Quigg RJ]]
[[Category: Immunology]]
[[Category: Repeat]]
[[Category: Scr]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan  7 20:08:38 2009''
Retrieved from "https://proteopedia.org/1ntj"