3fr2: Difference between revisions
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New page: '''Unreleased structure''' The entry 3fr2 is ON HOLD Authors: Barf, T, Hammer, K., Lehmann, F., Haile, S., Axen, E., Medina, C., Rondahl, L., Uppenberg, J., Svensson, S., Lundb ck, T. ... |
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==N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors== | |||
<StructureSection load='3fr2' size='340' side='right'caption='[[3fr2]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3fr2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FR2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8CA:9-BENZYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-8-CARBOXYLIC+ACID'>8CA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fr2 OCA], [https://pdbe.org/3fr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fr2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fr2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/3fr2_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fr2 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Axen E]] | |||
[[Category: Barf T]] | |||
[[Category: Haile S]] | |||
[[Category: Hammer K]] | |||
[[Category: Lehmann F]] | |||
[[Category: Lundb ck T]] | |||
[[Category: Medina C]] | |||
[[Category: Rondahl L]] | |||
[[Category: Svensson S]] | |||
[[Category: Uppenberg J]] | |||
Latest revision as of 09:50, 21 February 2024
N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors
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