3fr4: Difference between revisions

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New page: '''Unreleased structure''' The entry 3fr4 is ON HOLD Authors: Barf, T., Hammer, K., Lehmann, F., Haile, S., Axen, E., Medina, C., Uppenberg, J., Svensson, S., Rondahl, L., Lundb ck, T. ...
 
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'''Unreleased structure'''


The entry 3fr4 is ON HOLD
==N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors==
<StructureSection load='3fr4' size='340' side='right'caption='[[3fr4]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3fr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FR4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F8A:9-[2-(TRIFLUOROMETHYL)BENZYL]-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-8-CARBOXYLIC+ACID'>F8A</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fr4 OCA], [https://pdbe.org/3fr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fr4 RCSB], [https://www.ebi.ac.uk/pdbsum/3fr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fr4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/3fr4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fr4 ConSurf].
<div style="clear:both"></div>


Authors: Barf, T., Hammer, K., Lehmann, F., Haile, S., Axen, E., Medina, C., Uppenberg, J., Svensson, S., Rondahl, L., Lundb ck, T.
==See Also==
 
*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
Description: N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors
__TOC__
 
</StructureSection>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 12:56:15 2009''
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Axen E]]
[[Category: Barf T]]
[[Category: Haile S]]
[[Category: Hammer K]]
[[Category: Lehmann F]]
[[Category: Lundb ck T]]
[[Category: Medina C]]
[[Category: Rondahl L]]
[[Category: Svensson S]]
[[Category: Uppenberg J]]
Retrieved from "https://proteopedia.org/3fr4"