3fke: Difference between revisions

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{{Seed}}
[[Image:3fke.jpg|left|200px]]


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==Structure of the Ebola VP35 Interferon Inhibitory Domain==
The line below this paragraph, containing "STRUCTURE_3fke", creates the "Structure Box" on the page.
<StructureSection load='3fke' size='340' side='right'caption='[[3fke]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3fke]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. The October 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ebola Virus Proteins''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_10 10.2210/rcsb_pdb/mom_2014_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FKE FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fke OCA], [https://pdbe.org/3fke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fke RCSB], [https://www.ebi.ac.uk/pdbsum/3fke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fke ProSAT]</span></td></tr>
{{STRUCTURE_3fke|  PDB=3fke  |  SCENE=  }}
</table>
 
== Function ==
===Structure of the Ebola VP35 Interferon Inhibitory Domain===
[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
 
== References ==
 
<references/>
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[[Category: Ebola Virus Proteins]]
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[[Category: Ebola virus - Mayinga, Zaire, 1976]]
{{ABSTRACT_PUBMED_19122151}}
[[Category: Large Structures]]
 
[[Category: RCSB PDB Molecule of the Month]]
==About this Structure==
[[Category: Amarasinghe GK]]
3FKE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKE OCA].  
[[Category: Basler CF]]
 
[[Category: Fulton DB]]
==Reference==
[[Category: Ginder ND]]
Structure of the Ebola VP35 interferon inhibitory domain., Leung DW, Ginder ND, Fulton DB, Nix J, Basler CF, Honzatko RB, Amarasinghe GK, Proc Natl Acad Sci U S A. 2009 Jan 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19122151 19122151]
[[Category: Honzatko RB]]
[[Category: Viruses]]
[[Category: Leung DW]]
[[Category: Amarasinghe, G K.]]
[[Category: Nix J]]
[[Category: Basler, C F.]]
[[Category: Fulton, D B.]]
[[Category: Ginder, N D.]]
[[Category: Honzatko, R B.]]
[[Category: Leung, D W.]]
[[Category: Nix, J.]]
[[Category: Coiled coil]]
[[Category: Interferon antiviral system evasion]]
[[Category: Rna binding domain]]
[[Category: Rna binding protein]]
[[Category: Rna replication]]
[[Category: Rna-binding]]
[[Category: Transcription]]
 
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