1wfy: Difference between revisions
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New page: left|200px<br /><applet load="1wfy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wfy" /> '''Solution structure of the Ras-binding domain... |
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== | ==Solution structure of the Ras-binding domain of mouse RGS14== | ||
<StructureSection load='1wfy' size='340' side='right'caption='[[1wfy]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1wfy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WFY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wfy OCA], [https://pdbe.org/1wfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wfy RCSB], [https://www.ebi.ac.uk/pdbsum/1wfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wfy ProSAT], [https://www.topsan.org/Proteins/RSGI/1wfy TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RGS14_MOUSE RGS14_MOUSE] Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS1 and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division; required for completion of the first mitotic division of the embryo. Involved in visual memory processing capacity; when overexpressed in the V2 secondary visual cortex area. Involved in hippocampal-based learning and memory; acts as a suppressor of synaptic plasticity in CA2 neurons. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance.<ref>PMID:10926822</ref> <ref>PMID:15112653</ref> <ref>PMID:15525537</ref> <ref>PMID:15917656</ref> <ref>PMID:16246175</ref> <ref>PMID:20837545</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/1wfy_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wfy ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Inoue M]] | |||
[[Category: Inoue | [[Category: Kigawa T]] | ||
[[Category: Kigawa | [[Category: Koshiba S]] | ||
[[Category: Koshiba | [[Category: Nakanishi T]] | ||
[[Category: Nakanishi | [[Category: Tochio N]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Tochio | |||
[[Category: Yokoyama | |||
Latest revision as of 13:37, 9 May 2024
Solution structure of the Ras-binding domain of mouse RGS14
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