2zjn: Difference between revisions

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{{Seed}}
[[Image:2zjn.jpg|left|200px]]


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==Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(2-methyl-4-sulfamoyl-phenoxy)-acetamide==
The line below this paragraph, containing "STRUCTURE_2zjn", creates the "Structure Box" on the page.
<StructureSection load='2zjn' size='340' side='right'caption='[[2zjn]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2zjn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZJN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F1N:N-{1-[5-CHLORO-3-METHOXY-2-(1-METHYLETHOXY)BENZYL]PIPERIDIN-4-YL}-2-(2-METHYL-4-SULFAMOYLPHENOXY)ACETAMIDE'>F1N</scene></td></tr>
{{STRUCTURE_2zjn|  PDB=2zjn  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjn OCA], [https://pdbe.org/2zjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zjn RCSB], [https://www.ebi.ac.uk/pdbsum/2zjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zjn ProSAT]</span></td></tr>
 
</table>
===Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(2-methyl-4-sulfamoyl-phenoxy)-acetamide===
== Function ==
 
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2ZJN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJN OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/2zjn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zjn ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Large Structures]]
[[Category: Fahr, B T.]]
[[Category: Fahr BT]]
[[Category: Lam, M B.]]
[[Category: Lam MB]]
[[Category: Randal, M.]]
[[Category: Randal M]]
[[Category: Romanowski, M J.]]
[[Category: Romanowski MJ]]
[[Category: Alternative splicing]]
[[Category: Aspartyl protease]]
[[Category: Bace1]]
[[Category: Fragment-based discovery]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Membrane]]
[[Category: Protease]]
[[Category: Small-molecule inhibitor]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:40:46 2009''
Retrieved from "https://proteopedia.org/2zjn"