2zwh: Difference between revisions

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{{Seed}}
[[Image:2zwh.png|left|200px]]


<!--
==Model for the F-actin structure==
The line below this paragraph, containing "STRUCTURE_2zwh", creates the "Structure Box" on the page.
<StructureSection load='2zwh' size='340' side='right'caption='[[2zwh]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2zwh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZWH FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Fiber diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
{{STRUCTURE_2zwh|  PDB=2zwh  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zwh OCA], [https://pdbe.org/2zwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zwh RCSB], [https://www.ebi.ac.uk/pdbsum/2zwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zwh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Actin plays crucial parts in cell motility through a dynamic process driven by polymerization and depolymerization, that is, the globular (G) to fibrous (F) actin transition. Although our knowledge about the actin-based cellular functions and the molecules that regulate the G- to F-actin transition is growing, the structural aspects of the transition remain enigmatic. We created a model of F-actin using X-ray fibre diffraction intensities obtained from well oriented sols of rabbit skeletal muscle F-actin to 3.3 A in the radial direction and 5.6 A along the equator. Here we show that the G- to F-actin conformational transition is a simple relative rotation of the two major domains by about 20 degrees. As a result of the domain rotation, the actin molecule in the filament is flat. The flat form is essential for the formation of stable, helical F-actin. Our F-actin structure model provides the basis for understanding actin polymerization as well as its molecular interactions with actin-binding proteins.


===Model for the F-actin structure===
The nature of the globular- to fibrous-actin transition.,Oda T, Iwasa M, Aihara T, Maeda Y, Narita A Nature. 2009 Jan 22;457(7228):441-5. PMID:19158791<ref>PMID:19158791</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2zwh" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
2ZWH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZWH OCA].
*[[Actin 3D structures|Actin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Aihara, T.]]
[[Category: Aihara T]]
[[Category: Iwasa, M.]]
[[Category: Iwasa M]]
[[Category: Maeda, Y.]]
[[Category: Maeda Y]]
[[Category: Narita, A.]]
[[Category: Narita A]]
[[Category: Oda, T.]]
[[Category: Oda T]]
[[Category: Acetylation]]
[[Category: Atp-binding]]
[[Category: Contractile protein]]
[[Category: Cytoplasm]]
[[Category: Cytoskeleton]]
[[Category: Cytoskelton]]
[[Category: F-actin]]
[[Category: Fiber-diffraction]]
[[Category: G-actin]]
[[Category: Methylation]]
[[Category: Muscle protein]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
 
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Retrieved from "https://proteopedia.org/2zwh"