2w8m: Difference between revisions
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< | ==Structure of D212, a nuclease from a fusselovirus.== | ||
<StructureSection load='2w8m' size='340' side='right'caption='[[2w8m]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2w8m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_virus_Ragged_Hills Sulfolobus virus Ragged Hills]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W8M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w8m OCA], [https://pdbe.org/2w8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w8m RCSB], [https://www.ebi.ac.uk/pdbsum/2w8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w8m ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q6TRV5_9VIRU Q6TRV5_9VIRU] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Structural studies have made significant contributions to our understanding of Sulfolobus spindle-shaped viruses (Fuselloviridae), an important model system for archaeal viruses. Continuing these efforts, we report the structure of D212 from Sulfolobus spindle-shaped virus Ragged Hills. The overall fold and conservation of active site residues place D212 in the PD-(D/E)XK nuclease superfamily. The greatest structural similarity is found to the archaeal Holliday junction cleavage enzymes, strongly suggesting a role in DNA replication, repair, or recombination. Other roles associated with nuclease activity are also considered. | |||
The crystal structure of D212 from sulfolobus spindle-shaped virus ragged hills reveals a new member of the PD-(D/E)XK nuclease superfamily.,Menon SK, Eilers BJ, Young MJ, Lawrence CM J Virol. 2010 Jun;84(12):5890-7. Epub 2010 Apr 7. PMID:20375162<ref>PMID:20375162</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2w8m" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Sulfolobus virus Ragged Hills]] | ||
[[Category: | [[Category: Lawrence CM]] | ||
[[Category: | [[Category: Menon SK]] | ||
[[Category: Young MJ]] | |||
Latest revision as of 10:27, 27 September 2023
Structure of D212, a nuclease from a fusselovirus.
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