2zhk: Difference between revisions

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{{Seed}}
[[Image:2zhk.png|left|200px]]


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==Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine dimer (crystal 1)==
The line below this paragraph, containing "STRUCTURE_2zhk", creates the "Structure Box" on the page.
<StructureSection load='2zhk' size='340' side='right'caption='[[2zhk]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2zhk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZHK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
{{STRUCTURE_2zhk| PDB=2zhk |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhk OCA], [https://pdbe.org/2zhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zhk RCSB], [https://www.ebi.ac.uk/pdbsum/2zhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/2zhk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zhk ConSurf].
<div style="clear:both"></div>


===Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine dimer (crystal 1)===
==See Also==
 
*[[Galectin 3D structures|Galectin 3D structures]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_18977853}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 18977853 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_18977853}}
 
==About this Structure==
2ZHK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHK OCA].
 
==Reference==
Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain., Nagae M, Nishi N, Murata T, Usui T, Nakamura T, Wakatsuki S, Kato R, Glycobiology. 2009 Feb;19(2):112-7. Epub 2008 Oct 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18977853 18977853]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
[[Category: Kato R]]
[[Category: Alternative splicing]]
[[Category: Murata T]]
[[Category: Beta sandwich]]
[[Category: Nagae M]]
[[Category: Carbohydrate binding protein]]
[[Category: Nakamura T]]
[[Category: Cytoplasm]]
[[Category: Nishi N]]
[[Category: Galectin]]
[[Category: Usui T]]
[[Category: Polymorphism]]
[[Category: Wakatsuki S]]
[[Category: Secreted]]
[[Category: Sugar binding protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  4 20:19:33 2009''
Retrieved from "https://proteopedia.org/2zhk"