2pkd: Difference between revisions

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{{Seed}}
[[Image:2pkd.png|left|200px]]


<!--
==Crystal structure of CD84: Insite into SLAM family function==
The line below this paragraph, containing "STRUCTURE_2pkd", creates the "Structure Box" on the page.
<StructureSection load='2pkd' size='340' side='right'caption='[[2pkd]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2pkd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PKD FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.043&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
{{STRUCTURE_2pkd|  PDB=2pkd  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pkd OCA], [https://pdbe.org/2pkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pkd RCSB], [https://www.ebi.ac.uk/pdbsum/2pkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pkd ProSAT]</span></td></tr>
 
</table>
===Crystal structure of CD84: Insite into SLAM family function===
== Function ==
 
[https://www.uniprot.org/uniprot/SLAF5_HUMAN SLAF5_HUMAN] Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.<ref>PMID:11564780</ref> <ref>PMID:12115647</ref> <ref>PMID:12928397</ref> <ref>PMID:12962726</ref> <ref>PMID:16037392</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_17563375}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 17563375 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/2pkd_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_17563375}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2PKD is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKD OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pkd ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:17563375</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almo, S C.]]
[[Category: Large Structures]]
[[Category: Cao, E.]]
[[Category: Almo SC]]
[[Category: Cole, J L.]]
[[Category: Cao E]]
[[Category: Fedorov, A.]]
[[Category: Cole JL]]
[[Category: Lary, J W.]]
[[Category: Fedorov A]]
[[Category: Malashkevich, V N.]]
[[Category: Lary JW]]
[[Category: Nathenson, S G.]]
[[Category: Malashkevich VN]]
[[Category: Yan, Q.]]
[[Category: Nathenson SG]]
[[Category: Igc]]
[[Category: Yan Q]]
[[Category: Igv]]
[[Category: Immunoglobulin constant]]
[[Category: Immunoglobulin variable]]
[[Category: Signaling lymphocyte activation molecule]]
[[Category: Signaling protein]]
[[Category: Slam]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:26:20 2009''
Retrieved from "https://proteopedia.org/2pkd"