2f25: Difference between revisions

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{{Seed}}
[[Image:2f25.png|left|200px]]


<!--
==Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor==
The line below this paragraph, containing "STRUCTURE_2f25", creates the "Structure Box" on the page.
<StructureSection load='2f25' size='340' side='right'caption='[[2f25]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2f25]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F25 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
{{STRUCTURE_2f25| PDB=2f25 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f25 OCA], [https://pdbe.org/2f25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f25 RCSB], [https://www.ebi.ac.uk/pdbsum/2f25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f25 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f25_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f25 ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor===
==See Also==
 
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2F25 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F25 OCA].
[[Category: Exo-alpha-sialidase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chavas, L M.G.]]
[[Category: Large Structures]]
[[Category: Fusi, P.]]
[[Category: Chavas LMG]]
[[Category: Kato, R.]]
[[Category: Fusi P]]
[[Category: Monti, E.]]
[[Category: Kato R]]
[[Category: Tettamanti, G.]]
[[Category: Monti E]]
[[Category: Tringali, C.]]
[[Category: Tettamanti G]]
[[Category: Venerando, B.]]
[[Category: Tringali C]]
[[Category: Wakatsuki, S.]]
[[Category: Venerando B]]
[[Category: Drug design]]
[[Category: Wakatsuki S]]
[[Category: Ganglioside]]
[[Category: Neuraminidase]]
[[Category: Sialidase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:43:10 2009''
Retrieved from "https://proteopedia.org/2f25"