1xeq: Difference between revisions
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New page: left|200px<br /><applet load="1xeq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xeq, resolution 2.10Å" /> '''Crystal tructure of ... |
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== | ==Crystal tructure of RNA binding domain of influenza B virus non-structural protein== | ||
<StructureSection load='1xeq' size='340' side='right'caption='[[1xeq]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
[ | == Structural highlights == | ||
[[ | <table><tr><td colspan='2'>[[1xeq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Lee/1940) Influenza B virus (B/Lee/1940)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XEQ FirstGlance]. <br> | ||
[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr> | ||
[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xeq OCA], [https://pdbe.org/1xeq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xeq RCSB], [https://www.ebi.ac.uk/pdbsum/1xeq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xeq ProSAT], [https://www.topsan.org/Proteins/NESGC/1xeq TOPSAN]</span></td></tr> | ||
[ | </table> | ||
[ | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref> | ||
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==See Also== | |||
*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Khan JA]] | |||
[[Category: Krug RM]] | |||
[[Category: Montelione GT]] | |||
[[Category: Tong L]] | |||
[[Category: Yin C]] | |||
Latest revision as of 08:50, 14 February 2024
Crystal tructure of RNA binding domain of influenza B virus non-structural protein
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