1x81: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1x81.png|left|200px]]


<!--
==Farnesyl transferase structure of Jansen compound==
The line below this paragraph, containing "STRUCTURE_1x81", creates the "Structure Box" on the page.
<StructureSection load='1x81' size='340' side='right'caption='[[1x81]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1x81]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X81 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JAN:6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE'>JAN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1x81| PDB=1x81 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x81 OCA], [https://pdbe.org/1x81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x81 RCSB], [https://www.ebi.ac.uk/pdbsum/1x81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x81 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/1x81_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x81 ConSurf].
<div style="clear:both"></div>


===Farnesyl transferase structure of Jansen compound===
==See Also==
 
*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_15454228}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 15454228 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15454228}}
 
==About this Structure==
1X81 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X81 OCA].
 
==Reference==
<ref group="xtra">PMID:15454228</ref><references group="xtra"/>
[[Category: Protein farnesyltransferase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Claiborne, A.]]
[[Category: Claiborne A]]
[[Category: Cohen, J.]]
[[Category: Cohen J]]
[[Category: Frost, D.]]
[[Category: Frost D]]
[[Category: Gu, W.]]
[[Category: Gu W]]
[[Category: Hasvold, L.]]
[[Category: Hasvold L]]
[[Category: Hutchins, C.]]
[[Category: Hutchins C]]
[[Category: Jakob, C G.]]
[[Category: Jakob CG]]
[[Category: Li, Q.]]
[[Category: Li Q]]
[[Category: Li, T.]]
[[Category: Li T]]
[[Category: Muchmore, S.]]
[[Category: Muchmore S]]
[[Category: Rosenberg, S H.]]
[[Category: Rosenberg SH]]
[[Category: Sham, H L.]]
[[Category: Sham HL]]
[[Category: Stoll, V S.]]
[[Category: Stoll VS]]
[[Category: Fanesyltransferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:40:16 2009''
Retrieved from "https://proteopedia.org/1x81"