1m1a: Difference between revisions

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{{Seed}}
[[Image:1m1a.png|left|200px]]


<!--
==LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA==
The line below this paragraph, containing "STRUCTURE_1m1a", creates the "Structure Box" on the page.
<StructureSection load='1m1a' size='340' side='right'caption='[[1m1a]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1m1a]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M1A FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BAL:BETA-ALANINE'>BAL</scene>, <scene name='pdbligand=DIB:3-AMINO-(DIMETHYLPROPYLAMINE)'>DIB</scene>, <scene name='pdbligand=IMT:4-AMINO-(1-METHYLIMIDAZOLE)-2-CARBOXYLIC+ACID'>IMT</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYB:4-AMINO-(1-METHYLPYRROLE)-2-CARBOXYLIC+ACID'>PYB</scene></td></tr>
{{STRUCTURE_1m1a| PDB=1m1a |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1a OCA], [https://pdbe.org/1m1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m1a RCSB], [https://www.ebi.ac.uk/pdbsum/1m1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m1a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H3C_XENLA H3C_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/1m1a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m1a ConSurf].
<div style="clear:both"></div>


===LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA===
==See Also==
 
*[[Histone 3D structures|Histone 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_12559907}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 12559907 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12559907}}
 
==About this Structure==
1M1A is a 10 chains structure of sequences from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1A OCA].
 
==Reference==
<ref group="xtra">PMID:12559907</ref><references group="xtra"/>
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Dervan, P B.]]
[[Category: Dervan PB]]
[[Category: Edayathumangalam, R S.]]
[[Category: Edayathumangalam RS]]
[[Category: Gottesfeld, J M.]]
[[Category: Gottesfeld JM]]
[[Category: Luger, K.]]
[[Category: Luger K]]
[[Category: Melander, C.]]
[[Category: Melander C]]
[[Category: Suto, R K.]]
[[Category: Suto RK]]
[[Category: White, C L.]]
[[Category: White CL]]
[[Category: Chromatin]]
[[Category: Chromatin remodeling]]
[[Category: Dna regognition]]
[[Category: Histone]]
[[Category: Nucleosome]]
[[Category: Pyrrole-imidazole polyamide]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:23:34 2009''
Retrieved from "https://proteopedia.org/1m1a"