1xwv: Difference between revisions
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New page: left|200px<br /><applet load="1xwv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xwv, resolution 1.83Å" /> '''Structure of the hou... |
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== | ==Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity== | ||
The X-ray structure of the group 2 major allergen from Dermatophagoides | <StructureSection load='1xwv' size='340' side='right'caption='[[1xwv]], [[Resolution|resolution]] 1.83Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1xwv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XWV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=XPE:3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL'>XPE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xwv OCA], [https://pdbe.org/1xwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xwv RCSB], [https://www.ebi.ac.uk/pdbsum/1xwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xwv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ALL2_DERFA ALL2_DERFA] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xw/1xwv_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xwv ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes. | |||
Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity.,Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M FEBS Lett. 2005 Feb 14;579(5):1208-12. Epub 2005 Jan 21. PMID:15710415<ref>PMID:15710415</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1xwv" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dermatophagoides farinae]] | [[Category: Dermatophagoides farinae]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bolwig | [[Category: Bolwig C]] | ||
[[Category: Gajhede | [[Category: Gajhede M]] | ||
[[Category: Johannessen | [[Category: Johannessen BR]] | ||
[[Category: Kastrup | [[Category: Kastrup JS]] | ||
[[Category: Kristensen | [[Category: Kristensen O]] | ||
[[Category: Larsen | [[Category: Larsen JN]] | ||
[[Category: Lund | [[Category: Lund K]] | ||
[[Category: Skov | [[Category: Skov LK]] | ||
[[Category: Spangfort | [[Category: Spangfort M]] | ||
Latest revision as of 08:56, 6 November 2024
Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity
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