1xy2: Difference between revisions
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New page: left|200px<br /><applet load="1xy2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xy2, resolution 1.20Å" /> '''CRYSTAL STRUCTURE AN... |
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== | ==CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING== | ||
Two crystal structures of deamino-oxytocin have been determined at better | <StructureSection load='1xy2' size='340' side='right'caption='[[1xy2]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1xy2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XY2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPR:2-MERCAPTO-PROPION+ALDEHYDE'>MPR</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy2 OCA], [https://pdbe.org/1xy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xy2 RCSB], [https://www.ebi.ac.uk/pdbsum/1xy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xy2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NEU1_BOVIN NEU1_BOVIN] Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation. | |||
Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.,Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, Li JY, Husain J, Cooper S, Blundell TL, Hruby VJ, et al. Science. 1986 May 2;232(4750):633-6. PMID:3008332<ref>PMID:3008332</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: | <div class="pdbe-citations 1xy2" style="background-color:#fffaf0;"></div> | ||
[[Category: Blundell | == References == | ||
[[Category: Cooper | <references/> | ||
[[Category: Pitts | __TOC__ | ||
[[Category: Tickle | </StructureSection> | ||
[[Category: Wood | [[Category: Large Structures]] | ||
[[Category: Blundell TL]] | |||
[[Category: Cooper S]] | |||
[[Category: Pitts JE]] | |||
[[Category: Tickle IJ]] | |||
[[Category: Wood SP]] | |||
Latest revision as of 07:52, 12 July 2023
CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING
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