1y3y: Difference between revisions

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New page: left|200px<br /><applet load="1y3y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y3y, resolution 1.75Å" /> '''TRYPSIN INHIBITOR CO...
 
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[[Image:1y3y.gif|left|200px]]<br /><applet load="1y3y" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1y3y, resolution 1.75&Aring;" />
'''TRYPSIN INHIBITOR COMPLEX'''<br />


==About this Structure==
==TRYPSIN INHIBITOR COMPLEX==
1Y3Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CA and UIR as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Y3Y OCA].  
<StructureSection load='1y3y' size='340' side='right'caption='[[1y3y]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1y3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y3Y FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=UIR:(1R,3AS,4R,8AS,8BR)-4-(2-BENZO[1,3]DIOXOL-5-YL-1-CYCLOPROPYL-3-OXO-DECAHYDRO-PYRROLO[3,4-A]PYRROLIZIN-4-YL)-BENZAMIDINE'>UIR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3y OCA], [https://pdbe.org/1y3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y3y RCSB], [https://www.ebi.ac.uk/pdbsum/1y3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y3y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y3/1y3y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y3y ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
A simple protocol to estimate differences in protein binding affinity for enantiomers without prior resolution of racemates., Fokkens J, Klebe G, Angew Chem Int Ed Engl. 2006 Jan 30;45(6):985-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16374786 16374786]
*[[Trypsin 3D structures|Trypsin 3D structures]]
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Trypsin]]
[[Category: Fokkens J]]
[[Category: Fokkens, J.]]
[[Category: Klebe G]]
[[Category: Klebe, G.]]
[[Category: CA]]
[[Category: UIR]]
[[Category: 6 stranded beta-sheet]]
[[Category: barrel]]
[[Category: inhibitor complex]]
[[Category: trypsin]]
 
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