2d7f: Difference between revisions

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{{Seed}}
[[Image:2d7f.png|left|200px]]


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==Crystal structure of A lectin from canavalia gladiata seeds complexed with alpha-methyl-mannoside and alpha-aminobutyric acid==
The line below this paragraph, containing "STRUCTURE_2d7f", creates the "Structure Box" on the page.
<StructureSection load='2d7f' size='340' side='right'caption='[[2d7f]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2d7f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D7F FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
{{STRUCTURE_2d7f| PDB=2d7f |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d7f OCA], [https://pdbe.org/2d7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d7f RCSB], [https://www.ebi.ac.uk/pdbsum/2d7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d7f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d7/2d7f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d7f ConSurf].
<div style="clear:both"></div>


===Crystal structure of A lectin from canavalia gladiata seeds complexed with alpha-methyl-mannoside and alpha-aminobutyric acid===
==See Also==
 
*[[Concanavalin 3D structures|Concanavalin 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_17683532}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 17683532 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_17683532}}
 
==About this Structure==
2D7F is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D7F OCA].
 
==Reference==
<ref group="xtra">PMID:17683532</ref><references group="xtra"/>
[[Category: Canavalia gladiata]]
[[Category: Canavalia gladiata]]
[[Category: Cavada, B S.]]
[[Category: Large Structures]]
[[Category: Delatorre, P.]]
[[Category: Azevedo Jr WF]]
[[Category: Freitas, B T.]]
[[Category: Cavada BS]]
[[Category: Jr., W F.Azevedo.]]
[[Category: Delatorre P]]
[[Category: Moreno, F B.B M.]]
[[Category: Freitas BT]]
[[Category: Rocha, B A.M.]]
[[Category: Moreno FBBM]]
[[Category: Sampaio, A H.]]
[[Category: Rocha BAM]]
[[Category: Souza, E P.]]
[[Category: Sampaio AH]]
[[Category: Diocleinae]]
[[Category: Souza EP]]
[[Category: Lectin]]
[[Category: Nonprotein amino acid]]
[[Category: Plant protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:43:01 2009''

Latest revision as of 13:46, 13 March 2024

Crystal structure of A lectin from canavalia gladiata seeds complexed with alpha-methyl-mannoside and alpha-aminobutyric acid

2d7f, resolution 2.31Å

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