1s0u: Difference between revisions

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{{Seed}}
[[Image:1s0u.png|left|200px]]


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==eIF2gamma apo==
The line below this paragraph, containing "STRUCTURE_1s0u", creates the "Structure Box" on the page.
<StructureSection load='1s0u' size='340' side='right'caption='[[1s0u]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1s0u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S0U FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1s0u|  PDB=1s0u  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s0u OCA], [https://pdbe.org/1s0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s0u RCSB], [https://www.ebi.ac.uk/pdbsum/1s0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s0u ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IF2G_METJA IF2G_METJA] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s0/1s0u_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s0u ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The x-ray structure of the gamma-subunit of the heterotrimeric translation initiation factor eIF2 has been determined to 2.4-A resolution. eIF2 is a GTPase that delivers the initiator Met-tRNA to the P site on the small ribosomal subunit during a rate-limiting initiation step in translation. The structure of eIF2gamma closely resembles that of EF1A.GTP, consisting of an N-terminal G domain followed by two beta-barrels arranged in a closed configuration with domain II packed against the G domain in the vicinity of the Switch regions. The G domain of eIF2gamma has an unusual zinc ribbon motif, not previously found in other GTPases. Structure-based site-directed mutagenesis was used to identify two adjacent features on the surface of eIF2gamma that bind the alpha-subunit and Met-tRNA(i)(Met), respectively. These structural, biochemical, and genetic results provide new insights into eIF2 ternary complex assembly.


===eIF2gamma apo===
X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding.,Roll-Mecak A, Alone P, Cao C, Dever TE, Burley SK J Biol Chem. 2004 Mar 12;279(11):10634-42. Epub 2003 Dec 19. PMID:14688270<ref>PMID:14688270</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_14688270}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1s0u" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 14688270 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_14688270}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1S0U is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S0U OCA].
 
==Reference==
<ref group="xtra">PMID:14688270</ref><references group="xtra"/>
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Alone, P.]]
[[Category: Alone P]]
[[Category: Burley, S K.]]
[[Category: Burley SK]]
[[Category: Cao, C.]]
[[Category: Cao C]]
[[Category: Dever, T E.]]
[[Category: Dever TE]]
[[Category: Roll-Mecak, A.]]
[[Category: Roll-Mecak A]]
[[Category: Ef-1a]]
[[Category: Eif2]]
[[Category: Gtpase]]
[[Category: Translation initiation]]
[[Category: Trna]]
 
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Retrieved from "https://proteopedia.org/1s0u"