1l4a: Difference between revisions

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{{Seed}}
[[Image:1l4a.png|left|200px]]


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==X-RAY STRUCTURE OF THE NEURONAL COMPLEXIN/SNARE COMPLEX FROM THE SQUID LOLIGO PEALEI==
The line below this paragraph, containing "STRUCTURE_1l4a", creates the "Structure Box" on the page.
<StructureSection load='1l4a' size='340' side='right'caption='[[1l4a]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1l4a]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Doryteuthis_pealeii Doryteuthis pealeii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L4A FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4a OCA], [https://pdbe.org/1l4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l4a RCSB], [https://www.ebi.ac.uk/pdbsum/1l4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l4a ProSAT]</span></td></tr>
{{STRUCTURE_1l4a|  PDB=1l4a  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYB_DORPE SYB_DORPE] Intrinsic membrane protein of small synaptic vesicles.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l4/1l4a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l4a ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Nerve terminals release neurotransmitters from vesicles into the synaptic cleft upon transient increases in intracellular Ca(2+). This exocytotic process requires the formation of trans SNARE complexes and is regulated by accessory proteins including the complexins. Here we report the crystal structure of a squid core complexin-SNARE complex at 2.95-A resolution. A helical segment of complexin binds in anti-parallel fashion to the four-helix bundle of the core SNARE complex and interacts at its C terminus with syntaxin and synaptobrevin around the ionic zero layer of the SNARE complex. We propose that this structure is part of a multiprotein fusion machinery that regulates vesicle fusion at a late pre-fusion stage. Accordingly, Ca(2+) may initiate membrane fusion by acting directly or indirectly on complexin, thus allowing the conformational transitions of the trans SNARE complex that are thought to drive membrane fusion.


===X-RAY STRUCTURE OF THE NEURONAL COMPLEXIN/SNARE COMPLEX FROM THE SQUID LOLIGO PEALEI===
X-ray structure of a neuronal complexin-SNARE complex from squid.,Bracher A, Kadlec J, Betz H, Weissenhorn W J Biol Chem. 2002 Jul 19;277(29):26517-23. Epub 2002 May 9. PMID:12004067<ref>PMID:12004067</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1l4a" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_12004067}}, adds the Publication Abstract to the page
*[[Syntaxin 3D structures|Syntaxin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 12004067 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_12004067}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Doryteuthis pealeii]]
1L4A is a 5 chains structure of sequences from [http://en.wikipedia.org/wiki/Loligo_pealei Loligo pealei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4A OCA].
[[Category: Large Structures]]
 
[[Category: Betz H]]
==Reference==
[[Category: Bracher A]]
<ref group="xtra">PMID:12004067</ref><references group="xtra"/>
[[Category: Kadlec J]]
[[Category: Loligo pealei]]
[[Category: Weissenhorn W]]
[[Category: Betz, H.]]
[[Category: Bracher, A.]]
[[Category: Kadlec, J.]]
[[Category: Weissenhorn, W.]]
[[Category: Membrane fusion]]
[[Category: Neurotransmission]]
[[Category: Snare]]
[[Category: Snare complex]]
 
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Retrieved from "https://proteopedia.org/1l4a"