2riz: Difference between revisions

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{{Seed}}
[[Image:2riz.png|left|200px]]


<!--
==Unliganded B-specific-1,3-galactosyltransferase G176R mutant (ABBB)==
The line below this paragraph, containing "STRUCTURE_2riz", creates the "Structure Box" on the page.
<StructureSection load='2riz' size='340' side='right'caption='[[2riz]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2riz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RIZ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_2riz| PDB=2riz |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2riz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2riz OCA], [https://pdbe.org/2riz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2riz RCSB], [https://www.ebi.ac.uk/pdbsum/2riz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2riz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/2riz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2riz ConSurf].
<div style="clear:both"></div>


===Unliganded B-specific-1,3-galactosyltransferase G176R mutant (ABBB)===
==See Also==
 
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_18192272}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18192272 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_18192272}}
 
==Disease==
Known disease associated with this structure: Blood group, ABO system OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=110300 110300]]
 
==About this Structure==
2RIZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RIZ OCA].
 
==Reference==
<ref group="xtra">PMID:18192272</ref><references group="xtra"/>
[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Alfaro, J A.]]
[[Category: Large Structures]]
[[Category: Evans, S V.]]
[[Category: Alfaro JA]]
[[Category: Blood group antigen]]
[[Category: Evans SV]]
[[Category: Glycoprotein]]
[[Category: Glycosyltransferase]]
[[Category: Golgi apparatus]]
[[Category: Gtb abo rossman fold bbbb unliganded]]
[[Category: Manganese]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Polymorphism]]
[[Category: Secreted]]
[[Category: Signal-anchor]]
[[Category: Transferase]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:26:10 2009''

Latest revision as of 09:22, 21 February 2024

Unliganded B-specific-1,3-galactosyltransferase G176R mutant (ABBB)

2riz, resolution 1.45Å

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