1yq5: Difference between revisions
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New page: left|200px<br /><applet load="1yq5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yq5, resolution 2.0Å" /> '''PRD1 vertex protein P... |
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== | ==PRD1 vertex protein P5== | ||
Comparisons of bacteriophage PRD1 and adenovirus protein structures and | <StructureSection load='1yq5' size='340' side='right'caption='[[1yq5]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1yq5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacteria_phage_PRD1 Enterobacteria phage PRD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YQ5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yq5 OCA], [https://pdbe.org/1yq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yq5 RCSB], [https://www.ebi.ac.uk/pdbsum/1yq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yq5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/P5_BPPRD P5_BPPRD] In association with P31 and P2, forms the spike complexes located at the 5-fold vertices of the capsid. Essential for viral infectivity.<ref>PMID:10956048</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Comparisons of bacteriophage PRD1 and adenovirus protein structures and virion architectures have been instrumental in unraveling an evolutionary relationship and have led to a proposal of a phylogeny-based virus classification. The structure of the PRD1 spike protein P5 provides further insight into the evolution of viral proteins. The crystallized P5 fragment comprises two structural domains: a globular knob and a fibrous shaft. The head folds into a ten-stranded jelly roll beta barrel, which is structurally related to the tumor necrosis factor (TNF) and the PRD1 coat protein domains. The shaft domain is a structural counterpart to the adenovirus spike shaft. The structural relationships between PRD1, TNF, and adenovirus proteins suggest that the vertex proteins may have originated from an ancestral TNF-like jelly roll coat protein via a combination of gene duplication and deletion. | |||
The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture.,Merckel MC, Huiskonen JT, Bamford DH, Goldman A, Tuma R Mol Cell. 2005 Apr 15;18(2):161-70. PMID:15837420<ref>PMID:15837420</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: Enterobacteria phage | <div class="pdbe-citations 1yq5" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: Bamford | <references/> | ||
[[Category: Goldman | __TOC__ | ||
[[Category: Huiskonen | </StructureSection> | ||
[[Category: Merckel | [[Category: Enterobacteria phage PRD1]] | ||
[[Category: Tuma | [[Category: Large Structures]] | ||
[[Category: Bamford DH]] | |||
[[Category: Goldman A]] | |||
[[Category: Huiskonen JT]] | |||
[[Category: Merckel MC]] | |||
[[Category: Tuma R]] | |||
