2k86: Difference between revisions

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{{Seed}}
[[Image:2k86.png|left|200px]]


<!--
==Solution Structure of FOXO3a Forkhead domain==
The line below this paragraph, containing "STRUCTURE_2k86", creates the "Structure Box" on the page.
<StructureSection load='2k86' size='340' side='right'caption='[[2k86]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2k86]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K86 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k86 OCA], [https://pdbe.org/2k86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k86 RCSB], [https://www.ebi.ac.uk/pdbsum/2k86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k86 ProSAT]</span></td></tr>
{{STRUCTURE_2k86| PDB=2k86 |  SCENE= }}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/FOXO3_HUMAN FOXO3_HUMAN] Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with MLL/HRX.
== Function ==
[https://www.uniprot.org/uniprot/FOXO3_HUMAN FOXO3_HUMAN] Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.<ref>PMID:10102273</ref> <ref>PMID:16751106</ref> <ref>PMID:21329882</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/2k86_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k86 ConSurf].
<div style="clear:both"></div>


===Solution Structure of FOXO3a Forkhead domain===
==See Also==
 
*[[FOX 3D structures|FOX 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_18824006}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 18824006 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_18824006}}
 
==About this Structure==
2K86 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K86 OCA].
 
==Reference==
<ref group="xtra">PMID:18824006</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ikura, M.]]
[[Category: Large Structures]]
[[Category: Li, G.]]
[[Category: Ikura M]]
[[Category: Marshall, C B.]]
[[Category: Li G]]
[[Category: Plevin, M J.]]
[[Category: Marshall CB]]
[[Category: Wang, F.]]
[[Category: Plevin MJ]]
[[Category: Activator]]
[[Category: Wang F]]
[[Category: Apoptosis]]
[[Category: Chromosomal rearrangement]]
[[Category: Cytoplasm]]
[[Category: Dna binding domain]]
[[Category: Dna binding protein]]
[[Category: Dna-binding]]
[[Category: Forkhead]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Proto-oncogene]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Winged-helix]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:00:02 2009''
Retrieved from "https://proteopedia.org/2k86"