2hpo: Difference between revisions

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{{Seed}}
[[Image:2hpo.png|left|200px]]


<!--
==Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site==
The line below this paragraph, containing "STRUCTURE_2hpo", creates the "Structure Box" on the page.
<StructureSection load='2hpo' size='340' side='right'caption='[[2hpo]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2hpo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HPO FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2hpo| PDB=2hpo |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hpo OCA], [https://pdbe.org/2hpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hpo RCSB], [https://www.ebi.ac.uk/pdbsum/2hpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hpo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMPN_ECOLI AMPN_ECOLI] Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/2hpo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hpo ConSurf].
<div style="clear:both"></div>


===Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site===
==See Also==
 
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_16938892}}, adds the Publication Abstract to the page
[[Category: Escherichia coli K-12]]
(as it appears on PubMed at http://www.pubmed.gov), where 16938892 is the PubMed ID number.
[[Category: Large Structures]]
-->
[[Category: Addlagatta A]]
{{ABSTRACT_PUBMED_16938892}}
[[Category: Gay L]]
 
[[Category: Matthews BW]]
==About this Structure==
2HPO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HPO OCA].
 
==Reference==
<ref group="xtra">PMID:16938892</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Membrane alanyl aminopeptidase]]
[[Category: Addlagatta, A.]]
[[Category: Gay, L.]]
[[Category: Matthews, B W.]]
[[Category: Closed]]
[[Category: Compartmentalized active site]]
[[Category: Multidomain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:34:25 2009''
Retrieved from "https://proteopedia.org/2hpo"