2tbd: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2tbd.png|left|200px]]


<!--
==SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES==
The line below this paragraph, containing "STRUCTURE_2tbd", creates the "Structure Box" on the page.
<StructureSection load='2tbd' size='340' side='right'caption='[[2tbd]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2tbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta_polyomavirus_1 Macaca mulatta polyomavirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2TBD FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2tbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tbd OCA], [https://pdbe.org/2tbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2tbd RCSB], [https://www.ebi.ac.uk/pdbsum/2tbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2tbd ProSAT]</span></td></tr>
{{STRUCTURE_2tbd|  PDB=2tbd  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q98ZP7_SV40 Q98ZP7_SV40]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/2tbd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2tbd ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the domain from simian virus 40 (SV40) large T-antigen that binds to the SV40 origin of DNA replication (T-ag-OBD131-260) has been determined by nuclear magnetic resonance spectroscopy. The overall fold, consisting of a central five-stranded antiparallel beta-sheet flanked by two alpha-helices on one side and one alpha-helix and one 3(10)-helix on the other, is a new one. Previous mutational analyses have identified two elements, termed A (approximately 152-155) and B2 (203-207), as essential for origin-specific recognition. These elements form two closely juxtaposed loops that define a continuous surface on the protein. The addition of a duplex oligonucleotide containing the origin recognition pentanucleotide GAGGC induces chemical shift changes and slows amide proton exchange in resonances from this region, indicating that this surface directly contacts the DNA.


===SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES===
Solution structure of the origin DNA-binding domain of SV40 T-antigen.,Luo X, Sanford DG, Bullock PA, Bachovchin WW Nat Struct Biol. 1996 Dec;3(12):1034-9. PMID:8946857<ref>PMID:8946857</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2tbd" style="background-color:#fffaf0;"></div>


<!--
==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_8946857}}, adds the Publication Abstract to the page
*[[Large T Antigen|Large T Antigen]]
(as it appears on PubMed at http://www.pubmed.gov), where 8946857 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_8946857}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2TBD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TBD OCA].
[[Category: Macaca mulatta polyomavirus 1]]
 
[[Category: Bachovchin WW]]
==Reference==
[[Category: Bullock PA]]
<ref group="xtra">PMID:8946857</ref><references group="xtra"/>
[[Category: Luo X]]
[[Category: Simian virus 40]]
[[Category: Sanford DG]]
[[Category: Bachovchin, W W.]]
[[Category: Bullock, P A.]]
[[Category: Luo, X.]]
[[Category: Sanford, D G.]]
[[Category: Acetylation]]
[[Category: Dna-binding protein]]
[[Category: Early protein]]
[[Category: Nuclear protein]]
[[Category: Origin-binding domain]]
[[Category: Replication]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:56:36 2009''

Latest revision as of 09:45, 22 May 2024

SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2tbd&oldid=4158415"