2vli: Difference between revisions

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{{Seed}}
[[Image:2vli.png|left|200px]]


<!--
==Structure of Deinococcus radiodurans tunicamycin resistance protein==
The line below this paragraph, containing "STRUCTURE_2vli", creates the "Structure Box" on the page.
<StructureSection load='2vli' size='340' side='right'caption='[[2vli]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2vli]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deira Deira]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VLI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-->
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_2vli|  PDB=2vli  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vli OCA], [https://pdbe.org/2vli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vli RCSB], [https://www.ebi.ac.uk/pdbsum/2vli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vli ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vli_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vli ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The open-reading frame (ORF) DR_1419 in the Deinococcus radiodurans genome is annotated as a representative of the wide family of tunicamycin-resistance proteins as identified in a range of bacterial genomes. The D. radiodurans ORF DR_1419 was cloned and expressed; the protein TmrD was crystallized and its X-ray crystal structure was determined to 1.95 A resolution. The structure was determined using single-wavelength anomalous diffraction with selenomethionine-derivatized protein. The refined structure is the first to be reported for a member of the tunicamycin-resistance family. It reveals strong structural similarity to the family of nucleoside monophosphate kinases and to the chloramphenicol phosphotransferase of Streptomyces venezuelae, suggesting that the mode of action is possibly by phosphorylation of tunicamycin.


===STRUCTURE OF DEINOCOCCUS RADIODURANS TUNICAMYCIN RESISTANCE PROTEIN===
Structure of Deinococcus radiodurans tunicamycin-resistance protein (TmrD), a phosphotransferase.,Kapp U, Macedo S, Hall DR, Leiros I, McSweeney SM, Mitchell E Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):479-86., Epub 2008 May 16. PMID:18540055<ref>PMID:18540055</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
2VLI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLI OCA].
<div class="pdbe-citations 2vli" style="background-color:#fffaf0;"></div>
[[Category: Deinococcus radiodurans]]
== References ==
[[Category: Hall, D R.]]
<references/>
[[Category: Kapp, U.]]
__TOC__
[[Category: Leiros, I.]]
</StructureSection>
[[Category: Macedo, S.]]
[[Category: Deira]]
[[Category: Mitchell, E.]]
[[Category: Large Structures]]
[[Category: Antibiotic resistance]]
[[Category: Hall, D R]]
[[Category: Kapp, U]]
[[Category: Leiros, I]]
[[Category: Macedo, S]]
[[Category: Mitchell, E]]
[[Category: Phosphotransferase]]
[[Category: Phosphotransferase]]
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tunicamycin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:59:52 2009''

Latest revision as of 10:47, 7 July 2021

Structure of Deinococcus radiodurans tunicamycin resistance protein

2vli, resolution 1.95Å

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