3d27: Difference between revisions

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{{Seed}}
[[Image:3d27.png|left|200px]]


<!--
==E. coli methionine aminopeptidase with Fe inhibitor W29==
The line below this paragraph, containing "STRUCTURE_3d27", creates the "Structure Box" on the page.
<StructureSection load='3d27' size='340' side='right'caption='[[3d27]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3d27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D27 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=W29:4-(3-ETHYLTHIOPHEN-2-YL)BENZENE-1,2-DIOL'>W29</scene></td></tr>
{{STRUCTURE_3d27| PDB=3d27 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d27 OCA], [https://pdbe.org/3d27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d27 RCSB], [https://www.ebi.ac.uk/pdbsum/3d27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d27 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAP1_ECOLI MAP1_ECOLI] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]<ref>PMID:20521764</ref> <ref>PMID:3027045</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/3d27_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d27 ConSurf].
<div style="clear:both"></div>


===E. coli methionine aminopeptidase with Fe inhibitor W29===
==See Also==
 
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_18785729}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 18785729 is the PubMed ID number.
</StructureSection>
-->
[[Category: Escherichia coli K-12]]
{{ABSTRACT_PUBMED_18785729}}
[[Category: Large Structures]]
 
[[Category: Chai S]]
==About this Structure==
[[Category: He HZ]]
3D27 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D27 OCA].
[[Category: Ye QZ]]
 
==Reference==
<ref group="xtra">PMID:18785729</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Methionyl aminopeptidase]]
[[Category: Chai, S.]]
[[Category: He, H Z.]]
[[Category: Ye, Q Z.]]
[[Category: Aminopeptidase]]
[[Category: Cobalt]]
[[Category: Dinuclear]]
[[Category: Enzyme-inhibitor complex]]
[[Category: Hydrolase]]
[[Category: Iron]]
[[Category: Manganese]]
[[Category: Metal-binding]]
[[Category: Metalloenzyme]]
[[Category: Peptidase]]
[[Category: Protease]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:07:30 2009''

Latest revision as of 09:39, 21 February 2024

E. coli methionine aminopeptidase with Fe inhibitor W29

3d27, resolution 2.20Å

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