3b7l: Difference between revisions

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{{Seed}}
[[Image:3b7l.png|left|200px]]


<!--
==Human farnesyl diphosphate synthase complexed with MG and minodronate==
The line below this paragraph, containing "STRUCTURE_3b7l", creates the "Structure Box" on the page.
<StructureSection load='3b7l' size='340' side='right'caption='[[3b7l]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3b7l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B7L FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M0N:(1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC+ACID)'>M0N</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_3b7l| PDB=3b7l |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7l OCA], [https://pdbe.org/3b7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7l RCSB], [https://www.ebi.ac.uk/pdbsum/3b7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/3b7l_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b7l ConSurf].
<div style="clear:both"></div>


===Human farnesyl diphosphate synthase complexed with MG and minodronate===
==See Also==
 
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3B7L is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7L OCA].
[[Category: Geranyltranstransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Delft, F Von.]]
[[Category: Arrowsmith CH]]
[[Category: Dunford, J E.]]
[[Category: Dunford JE]]
[[Category: Ebetino, F H.]]
[[Category: Ebetino FH]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Guo, K.]]
[[Category: Guo K]]
[[Category: Kavanagh, K L.]]
[[Category: Kavanagh KL]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: Pike, A C.W.]]
[[Category: Pike ACW]]
[[Category: Pilka, E S.]]
[[Category: Pilka ES]]
[[Category: Russell, R G.G.]]
[[Category: Russell RGG]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Von Delft F]]
[[Category: Bisphosphonate]]
[[Category: Cholesterol biosynthesis]]
[[Category: Cholesterol synthesis]]
[[Category: Cytoplasm]]
[[Category: Host-virus interaction]]
[[Category: Isoprene biosynthesis]]
[[Category: Isoprenoid pathway]]
[[Category: Lipid synthesis]]
[[Category: Sgc]]
[[Category: Steroid biosynthesis]]
[[Category: Sterol biosynthesis]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:48:01 2009''

Latest revision as of 12:03, 30 August 2023

Human farnesyl diphosphate synthase complexed with MG and minodronate

3b7l, resolution 1.95Å

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