2alj: Difference between revisions

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{{Seed}}
[[Image:2alj.png|left|200px]]


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==Structure of the cis confomer of the major extracytoplasmic domain of the bacterial cell division protein divib from geobacillus stearothermophilus==
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<StructureSection load='2alj' size='340' side='right'caption='[[2alj]]' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2alj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ALJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ALJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2alj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2alj OCA], [https://pdbe.org/2alj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2alj RCSB], [https://www.ebi.ac.uk/pdbsum/2alj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2alj ProSAT]</span></td></tr>
{{STRUCTURE_2alj|  PDB=2alj  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/DIVIB_GEOKA DIVIB_GEOKA] Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.[HAMAP-Rule:MF_00912]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/al/2alj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2alj ConSurf].
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== Publication Abstract from PubMed ==
Bacterial cytokinesis requires the coordinated assembly of a complex of proteins, collectively known as the divisome, at the incipient division site. DivIB/FtsQ is a conserved component of the divisome in bacteria with cell walls, suggesting that it plays a role in synthesis and/or remodeling of septal peptidoglycan. We demonstrate that the extracytoplasmic region of DivIB comprises three discrete domains that we designate alpha, beta, and gamma from the N to C terminus. The alpha-domain is proximal to the cytoplasmic membrane and coincident with the polypeptide transport-associated domain that was proposed previously to function as a molecular chaperone. The beta-domain has a unique 3D fold, with no eukaryotic counterpart, and we show that it interconverts between two discrete conformations via cis-trans isomerization of a Tyr-Pro peptide bond. We propose that this isomerization might modulate protein-protein interactions of the flanking alpha- and gamma-domains. The C-terminal gamma-domain is unstructured in the absence of other divisomal proteins, but we show that it is critical for DivIB function.


===Structure of the cis confomer of the major extracytoplasmic domain of the bacterial cell division protein divib from geobacillus stearothermophilus===
Domain architecture and structure of the bacterial cell division protein DivIB.,Robson SA, King GF Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6700-5. Epub 2006 Apr 17. PMID:16618922<ref>PMID:16618922</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 16618922 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_16618922}}
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</StructureSection>
==About this Structure==
2ALJ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ALJ OCA].
 
==Reference==
<ref group="xtra">PMID:16618922</ref><references group="xtra"/>
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
[[Category: King, G F.]]
[[Category: Large Structures]]
[[Category: Robson, S A.]]
[[Category: King GF]]
[[Category: Cell-division initiation protein]]
[[Category: Robson SA]]
[[Category: Divib]]
[[Category: Divisome]]
[[Category: Ftsq]]
 
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Retrieved from "https://proteopedia.org/2alj"