2g76: Difference between revisions

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{{Seed}}
[[Image:2g76.png|left|200px]]


<!--
==Crystal structure of human 3-phosphoglycerate dehydrogenase==
The line below this paragraph, containing "STRUCTURE_2g76", creates the "Structure Box" on the page.
<StructureSection load='2g76' size='340' side='right'caption='[[2g76]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2g76]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G76 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
{{STRUCTURE_2g76| PDB=2g76 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g76 OCA], [https://pdbe.org/2g76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g76 RCSB], [https://www.ebi.ac.uk/pdbsum/2g76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g76 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
== Function ==
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g76_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g76 ConSurf].
<div style="clear:both"></div>


===Crystal structure of human 3-phosphoglycerate dehydrogenase===
==See Also==
 
*[[Phosphoglycerate dehydrogenase|Phosphoglycerate dehydrogenase]]
 
__TOC__
==About this Structure==
</StructureSection>
2G76 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G76 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoglycerate dehydrogenase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Delft, F von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Gileadi O]]
[[Category: Gileadi, O.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Salah E]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Savitsky P]]
[[Category: Salah, E.]]
[[Category: Sundstrom M]]
[[Category: Savitsky, P.]]
[[Category: Turnbull AP]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Turnbull, A P.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: 2-hydroxyacid dehydrogenase]]
[[Category: Oxidoreductase]]
[[Category: Phosphoglycerate dehydrogenase deficiency]]
[[Category: Serine metabolism]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:58:08 2009''
Retrieved from "https://proteopedia.org/2g76"