1zgr: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
New page: left|200px<br /><applet load="1zgr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zgr, resolution 2.50Å" /> '''Crystal structure of...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(15 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1zgr.gif|left|200px]]<br /><applet load="1zgr" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1zgr, resolution 2.50&Aring;" />
'''Crystal structure of the Parkia platycephala seed lectin'''<br />


==Overview==
==Crystal structure of the Parkia platycephala seed lectin==
The crystal structures of the apo and mannose-bound Parkia platycephala, seed lectin represent the first structure of a Mimosoideae lectin and a, novel circular arrangement of beta-prism domains, and highlight the, adaptability of the beta-prism fold as a building block in the evolution, of plant lectins. The P.platycephala lectin is a dimer both in solution, and in the crystals. Mannose binding to each of the three homologous, carbohydrate-recognition domains of the lectin occurs through different, modes, and restrains the flexibility of surface-exposed loops and residues, involved in carbohydrate recognition. The planar array of, carbohydrate-binding sites on the rim of the toroid-shaped structure of, the P.platycephala lectin dimer immediately suggests a mechanism to, promote multivalent interactions leading to cross-linking of carbohydrate, ligands as part of the host strategy against phytopredators and pathogens., The cyclic structure of the P.platycephala lectin points to the convergent, evolution of a structural principle for the construction of lectins, involved in host defense or in attacking other organisms.
<StructureSection load='1zgr' size='340' side='right'caption='[[1zgr]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1zgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Parkia_platycephala Parkia platycephala]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZGR FirstGlance]. <br>
1ZGR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Parkia_platycephala Parkia platycephala]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZGR OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zgr OCA], [https://pdbe.org/1zgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zgr RCSB], [https://www.ebi.ac.uk/pdbsum/1zgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zgr ProSAT]</span></td></tr>
==Reference==
</table>
The first crystal structure of a Mimosoideae lectin reveals a novel quaternary arrangement of a widespread domain., Gallego del Sol F, Nagano C, Cavada BS, Calvete JJ, J Mol Biol. 2005 Oct 28;353(3):574-83. Epub 2005 Sep 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16185708 16185708]
== Function ==
[https://www.uniprot.org/uniprot/LEC_PARPC LEC_PARPC] Mannose/glucose specific lectin. Shows agglutinating activity against rabbit erythrocytes.<ref>PMID:11502201</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/1zgr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zgr ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Parkia platycephala]]
[[Category: Parkia platycephala]]
[[Category: Single protein]]
[[Category: Calvete JJ]]
[[Category: Calvete, J.J.]]
[[Category: Cavada BS]]
[[Category: Cavada, B.S.]]
[[Category: Gallego del Sol F]]
[[Category: Sol, F.Gallego.del.]]
[[Category: beta-prism]]
[[Category: lectin]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 07:26:29 2007''

Latest revision as of 13:39, 13 March 2024

Crystal structure of the Parkia platycephala seed lectin

1zgr, resolution 2.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1zgr&oldid=4088295"