3dck: Difference between revisions

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{{Seed}}
[[Image:3dck.png|left|200px]]


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==X-ray structure of D25N chemical analogue of HIV-1 protease complexed with ketomethylene isostere inhibitor==
The line below this paragraph, containing "STRUCTURE_3dck", creates the "Structure Box" on the page.
<StructureSection load='3dck' size='340' side='right'caption='[[3dck]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3dck]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DCK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DCK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=KVI:(2S)-2-{[(2R,5S)-5-{[(2S,3S)-2-{[(2S,3R)-2-(acetylamino)-3-hydroxybutanoyl]amino}-3-methylpentanoyl]amino}-2-butyl-4-oxononanoyl]amino}-N~1~-[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]pentanediamide'>KVI</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
{{STRUCTURE_3dck|  PDB=3dck  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dck OCA], [https://pdbe.org/3dck PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dck RCSB], [https://www.ebi.ac.uk/pdbsum/3dck PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dck ProSAT]</span></td></tr>
 
</table>
===X-ray structure of D25N chemical analogue of HIV-1 protease complexed with ketomethylene isostere inhibitor===
== Function ==
 
[https://www.uniprot.org/uniprot/O38732_9HIV1 O38732_9HIV1]  
 
== Evolutionary Conservation ==
<!--
[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_18657969}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 18657969 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/3dck_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_18657969}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
3DCK is a 3 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DCK OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dck ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
<ref group="xtra">PMID:18657969</ref><references group="xtra"/>
</StructureSection>
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Kent, S B.H.]]
[[Category: Large Structures]]
[[Category: Mandal, K.]]
[[Category: Kent SBH]]
[[Category: Terechko, V A.]]
[[Category: Mandal K]]
[[Category: Torbeev, V Y.]]
[[Category: Terechko VA]]
[[Category: Beta-strand]]
[[Category: Torbeev VY]]
[[Category: Beta-turn]]
[[Category: Hiv-1 protease]]
[[Category: Homodimer]]
[[Category: Hydrolase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:20:19 2009''

Latest revision as of 08:23, 20 March 2024

X-ray structure of D25N chemical analogue of HIV-1 protease complexed with ketomethylene isostere inhibitor

3dck, resolution 1.80Å

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