1r17: Difference between revisions
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< | ==Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (adhesin-ligand complex)== | ||
<StructureSection load='1r17' size='340' side='right'caption='[[1r17]], [[Resolution|resolution]] 1.86Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1r17]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R17 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r17 OCA], [https://pdbe.org/1r17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r17 RCSB], [https://www.ebi.ac.uk/pdbsum/1r17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r17 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SDRG_STAEP SDRG_STAEP] Binds to the N-terminus of the B beta-chain of human fibrinogen and thereby interferes with thrombin cleavage and release of fibrinopeptide B, thus interfering with fibrin clot formation. This may hinder host defense against microbial infections.<ref>PMID:11371571</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r17_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r17 ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Fibrinogen binding protein|Fibrinogen binding protein]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
== | |||
< | |||
[[Category: Staphylococcus epidermidis]] | [[Category: Staphylococcus epidermidis]] | ||
[[Category: Bowden | [[Category: Bowden MG]] | ||
[[Category: Choe | [[Category: Choe D]] | ||
[[Category: Davis | [[Category: Davis S]] | ||
[[Category: Gurusiddappa | [[Category: Gurusiddappa S]] | ||
[[Category: Hook | [[Category: Hook M]] | ||
[[Category: Moore | [[Category: Moore D]] | ||
[[Category: Narayana | [[Category: Narayana SVL]] | ||
[[Category: Ponnuraj | [[Category: Ponnuraj K]] | ||
[[Category: Xu | [[Category: Xu Y]] | ||
Latest revision as of 08:19, 14 February 2024
Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (adhesin-ligand complex)
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