2k28: Difference between revisions

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{{Seed}}
[[Image:2k28.png|left|200px]]


<!--
==Solution NMR structure of the chromo domain of the chromobox protein homolog 4==
The line below this paragraph, containing "STRUCTURE_2k28", creates the "Structure Box" on the page.
<StructureSection load='2k28' size='340' side='right'caption='[[2k28]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2k28]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K28 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k28 OCA], [https://pdbe.org/2k28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k28 RCSB], [https://www.ebi.ac.uk/pdbsum/2k28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k28 ProSAT]</span></td></tr>
{{STRUCTURE_2k28|  PDB=2k28  |  SCENE=  }}
</table>
 
== Function ==
===Solution NMR structure of the chromo domain of the chromobox protein homolog 4===
[https://www.uniprot.org/uniprot/CBX4_HUMAN CBX4_HUMAN] E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression.<ref>PMID:12679040</ref> <ref>PMID:16061479</ref> <ref>PMID:17018294</ref> <ref>PMID:21282530</ref> <ref>PMID:22825850</ref>  Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.<ref>PMID:12679040</ref> <ref>PMID:16061479</ref> <ref>PMID:17018294</ref> <ref>PMID:21282530</ref> <ref>PMID:22825850</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2K28 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K28 OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k28_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k28 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Edwards, A M.]]
[[Category: Bountra C]]
[[Category: Fares, C.]]
[[Category: Edwards AM]]
[[Category: Gutmanas, A.]]
[[Category: Fares C]]
[[Category: Kaustov, L.]]
[[Category: Gutmanas A]]
[[Category: Lemak, A.]]
[[Category: Kaustov L]]
[[Category: Loppnau, P.]]
[[Category: Lemak A]]
[[Category: Min, J.]]
[[Category: Loppnau P]]
[[Category: Quyang, H.]]
[[Category: Min J]]
[[Category: Ravichandran, M.]]
[[Category: Quyang H]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Ravichandran M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Alpha/beta protein]]
[[Category: Alternative splicing]]
[[Category: Chromatin regulator]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Repressor]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Ubl conjugation]]
[[Category: Ubl conjugation pathway]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:38:39 2009''

Latest revision as of 09:43, 9 May 2024

Solution NMR structure of the chromo domain of the chromobox protein homolog 4

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