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New page: left|200px<br /> <applet load="2cit" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cit, resolution 1.40Å" /> '''STRUCTURE OF THE CO...
 
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[[Image:2cit.gif|left|200px]]<br />
<applet load="2cit" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2cit, resolution 1.40&Aring;" />
'''STRUCTURE OF THE COVALENT INTERMEDIATE OF A FAMILY 26 LICHENASE'''<br />


==About this Structure==
==Structure of the covalent intermediate of a family 26 lichenase==
2CIT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Clostridium_thermocellum Clostridium thermocellum]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.4 3.2.1.4]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CIT OCA]].  
<StructureSection load='2cit' size='340' side='right'caption='[[2cit]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetivibrio_thermocellus Acetivibrio thermocellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=G2F:2-DEOXY-2-FLUORO-ALPHA-D-GLUCOPYRANOSE'>G2F</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cit OCA], [https://pdbe.org/2cit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cit RCSB], [https://www.ebi.ac.uk/pdbsum/2cit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cit ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GUNH_ACET2 GUNH_ACET2] This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cit_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cit ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Substrate distortion by a lichenase highlights the different conformational itineraries harnessed by related glycoside hydrolases., Money VA, Smith NL, Scaffidi A, Stick RV, Gilbert HJ, Davies GJ, Angew Chem Int Ed Engl. 2006 Aug 4;45(31):5136-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16823793 16823793]
*[[Glucanase 3D structures|Glucanase 3D structures]]
[[Category: Clostridium thermocellum]]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Davies, G.J.]]
[[Category: Acetivibrio thermocellus]]
[[Category: Gilbert, H.J.]]
[[Category: Large Structures]]
[[Category: Money, V.A.]]
[[Category: Davies GJ]]
[[Category: Scaffidi, A.]]
[[Category: Gilbert HJ]]
[[Category: Smith, N.L.]]
[[Category: Money VA]]
[[Category: Stick, R.V.]]
[[Category: Scaffidi A]]
[[Category: 3 glucanase]]
[[Category: Smith NL]]
[[Category: 4 beta-1]]
[[Category: Stick RV]]
[[Category: beta-1]]
[[Category: carbohydrate metabolism]]
[[Category: cellulose degradation]]
[[Category: glycosidase]]
[[Category: glycoside hydrolase]]
[[Category: hydrolase]]
[[Category: lichenase]]
[[Category: michaelis complex]]
[[Category: polysaccharide degradation]]
 
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