2f89: Difference between revisions

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{{Seed}}
[[Image:2f89.png|left|200px]]


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==Crystal structure of human FPPS in complex with pamidronate==
The line below this paragraph, containing "STRUCTURE_2f89", creates the "Structure Box" on the page.
<StructureSection load='2f89' size='340' side='right'caption='[[2f89]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2f89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F89 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_2f89| PDB=2f89 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f89 OCA], [https://pdbe.org/2f89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f89 RCSB], [https://www.ebi.ac.uk/pdbsum/2f89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f89 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/2f89_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f89 ConSurf].
<div style="clear:both"></div>


===Crystal structure of human FPPS in complex with pamidronate===
==See Also==
 
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_16892359}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16892359 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16892359}}
 
==About this Structure==
2F89 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F89 OCA].
 
==Reference==
<ref group="xtra">PMID:16892359</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bitsch, F.]]
[[Category: Large Structures]]
[[Category: Bourgier, E.]]
[[Category: Bitsch F]]
[[Category: Geiser, M.]]
[[Category: Bourgier E]]
[[Category: Green, J R.]]
[[Category: Geiser M]]
[[Category: Hemmig, R.]]
[[Category: Green JR]]
[[Category: Jahnke, W.]]
[[Category: Hemmig R]]
[[Category: Kroemer, M.]]
[[Category: Jahnke W]]
[[Category: Lehmann, S.]]
[[Category: Kroemer M]]
[[Category: Ramage, P.]]
[[Category: Lehmann S]]
[[Category: Rieffel, S.]]
[[Category: Ramage P]]
[[Category: Rondeau, J M.]]
[[Category: Rieffel S]]
[[Category: Strauss, A.]]
[[Category: Rondeau J-M]]
[[Category: Bisphosphonate inhibitor]]
[[Category: Strauss A]]
[[Category: Cholesterol biosynthesis]]
[[Category: Isoprene biosynthesis]]
[[Category: Mevalonate pathway]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:51:21 2009''

Latest revision as of 09:21, 14 February 2024

Crystal structure of human FPPS in complex with pamidronate

2f89, resolution 2.60Å

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